Inflammaging refers to a low-level, yet chronic inflammation associated with premature aging of tissues, including skin. A silent threat, it damages tissues through three main mechanisms:

increased glycation, ROS production and release of pro-inflammatory cytokines.

Sinerga R&D developed an innovative ingredient (Carobosoothe) that, besides counteracting these mechanisms, is able to stop the intrinsic processes of inflammaging through the stimulation of aquaporins, a family of membrane channels proteins necessary for various vital functions, including cellular migration, cellular proliferation, as well as mitochondria functioning and protection from ROS.

By enhancing the expression of these key biological processes, Carobsoothe fosters the maintenance of cellular health and homeostasis, therefore slowing down cellular senescence and damages caused by inflammation. 

Aquaporins are able to inhibit inflammaging both:

• Directly: thanks to their role in regulating mitochondrial functionality and keratinocytes differentiation, they directly slow down cellular senescence and inflammatory response;
• Indirectly: they stimulate physiological processes of protection against aging, maintaining correct cellular activity (autophagy) and ROS protection, which both slow down with age .

This activity, combined with its radical scavenging and anti-inflammatory properties, allows Carobsoothe to obtain a healthy, young complexion, preventing the main symptoms related to inflammaging: dehydration, sagging, dullness, dyschromia, redness.

Indeed, Carobsoothe is able to enhance a healthy glow, reducing redness and greyish aspect, while also increasing elasticity, hydrating, calming redness and preventing TEWL.

Discover more about Carobsoothe!