Oxi-inflammaging is a term that combines oxidative stress and inflammaging (the low-grande yet constant inflammation that affects body tissues and is behing several pathologies as well as premature aging of skin tissues).

It refers to the synergistic negative interaction between the build-up of Reactive Oxygen Species (ROS) and the continuous production of pro-inflammatory cytokines, creating a vicious circle: inflammaging fuel ROS release that damage cells, which furtherly release inflammatory cytokines.

Indeed, as we age our natural antioxidant defenses weaken while exposure to elements like UV radiation, pollution, stress and poor lifestyle habits increases ROS release and therefore oxidative damage. This imbalance amplifies the persistent micro-inflammation and reduce the ability of cells to control it, accelerating collagen breakdown, impairing skin barrier function, and reducing cellular regeneration.

As a result, oxi-inflammaging manifests as wrinkles and sagging skin, dull and greyish complexion, uneven tone, dryness and increased sensitivity. At a deeper level, it affects fibroblasts, extracellular matrix integrity and overall tissue resilience.

Today, the concept of oxi-inflammaging is shaping next-generation skincare strategies: modern formulations aim not only to neutralize free radicals but also to modulate inflammatory pathways and strengthen the skin’s defense systems, creating a comprehensive solution targeting all the different features of this biological phenomenon.

SINERGA SOLUTION:

Leniphenol is a natural extract derived from the bark of certified industrial wood, following FSC process. It is able to counteract oxy-inflammaging through a multi-way approach:

• The activation of antioxidant enzyme SOD - Superoxidase Dismusate (+75%) and the inhibition of ROS (-94%), reducing therefore the build-up of ROS and providing cells with direct, endogenous defensive mechanisms.
• It prevents chronic inflammation, inhibiting pro-inflammatory cytokines (-24%) and allergic response (-7.5%).
• Preserves the structure of extra-cellular matrix, enhancing skin structural integrity and resilience (-36% and -30% of the enzymes responsible for degradating the structural components of the matrix).
• Protects cell viability from pollutants (+22% after exposure) and UV rays (-4% erythema after exposure), who may lead to epigenetic modifications.

Carobsoothe is a 100% natural ingredient following up-cycling beauty. It targets the main mechanisms of oxy-inflammaging as it is able to both address inflammatory pathways (inhibiting pro-inflammatory cytokines as well as calming erythema) and stimulate endogenous anti-oxidant defenses:

• It increases the scavenging activity in cells (+18% anti-oxidant defense).
• It prevents chronic inflammation, inhibiting pro-inflammatory cytokines mainly involved in inflammaging (-27% and -31%)
• Soothes skin by reducing erythema in just 30 minutes (-34%)

This results in in an overall improvement of skin health, which is more hydrated (+17%), elastic (+21%) and glowing (+6%), and at the same time with no redness and dyschromia (-12%) and reduced dryness (-16% TEWL).